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INSPIRE: INternational Stroke Perfusion Imaging Registry

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INSPIRE: INternational Stroke Perfusion Imaging REgistry

Lead PI:  John Hunter Hospital

Status: Recruiting

No. of Patients Currently Recruited: 1500                       No. of Patients Required: 2000

INSPIRE is an international web-based database collecting imaging and clinical stroke data to measure implementation of advanced CT image in stroke, So far, INSPIRE has recruited around 1500 patients from sitesacross Australi, China Canada and India. The fist stage of data analysis has been completed, leading to 4 research papers (3 ongoing and 1 published).

Trial URL:





Last Updated ( Friday, 15 July 2016 16:22 )

CHARM: Cirara in large Hemispheric infarction Analysing mRS and Mortality

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Lead PI: Dr Bruce Campbell

Status: ASTN endorsed

No. of Patients Currently Recruited: 0                                No. of Patients Required: tbc

Edema in larger hemispheric infarction can cause neurological deterioration and death. Intravenous glyburide acts on SUR-1 receptors to reduce edema after ischemic stroke. The hypothesis of the CHARM phase 3 randomised trial is that intravenous glyburide will improve the functional outcome after large hemispheric stroke compared to placebo.
Last Updated ( Thursday, 07 July 2016 14:07 )

EXTEND-IA TNK: Extending the time for thrombolysis in emergency neurological deficits - intra-arterial with tenecteplase

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Lead PI: Dr Bruce Campbell

Status: Recruiting / Site Selection

 No. of Patients Currently Recruited: 53                                No. of Patients Required:  tbc

Rapid reperfusion is the key to improved ischemic stroke outcomes. Tenecteplase may be safer and more effective than alteplase. The hypothesis of the EXTEND-IA TNK randomised trial is that intravenous tenecteplase will achieve reperfusion prior to cerebral angiography more frequently than intravenous alteplase in patients eligible for clot retrieval.

Trial URL:

Clinicaltrials.gov NCT02388061


Last Updated ( Wednesday, 06 July 2016 14:49 )

VERSE: Very Early Rehabilitation in Speech after Stroke

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Lead PI: Associate Professor Erin Godecke

Status: Recruiting


No. of Patients Currently Recruited: 123                                No. of Patients Required:  246


This 3-arm randomised controlled trial (RCT) aims to determine whether a standardised, intensive aphasia therapy regimen (VERSE) is more effective and cost saving than intensive non-standardised usual care training (UC-Plus) and regular usual care (US) therapy provided at 12 weeks post stroke.


Trial URL:

ANZCTR No: ACTRN12613000776707





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